Drug Discovery Platform
Unlocking Molecular Interactions for Complex Biology
Our Drug Discovery Platform integrates state-of-the-art analytical technologies with expert scientific support to advance molecular research and therapeutic development.We provide comprehensive analytical and discovery services focused on drug–target interactions, drug library virtual screening, and molecular characterization, as well as studies of small molecules, metabolomics, and lipidomics in tissue, plasma, and cell samples.By combining Nuclear Magnetic Resonance (NMR), Liquid Chromatography–Mass Spectrometry (LC–MS), and in silico computational approaches, our multidisciplinary team delivers reliable, publication-ready insights that accelerate lead identification and translational discovery.​
NMR Service
Our Nuclear Magnetic Resonance (NMR) platform offers comprehensive small-molecule and biomolecular analyses, with workflows optimized for throughput and data quality.
With decades of experience and a suite of robustly validated applications, our NMR services include:
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Performing qualitative and quantitative analysis of small molecules
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Determining the structures of organic molecules and small peptides
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Assessing the purity of small-molecule samples or mixtures
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Conducting metabolomic studies on biological samples (urine, serum, tissue, and cell culture)
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Applying ligand-observed NMR (WaterLOGSY and STD-NMR) experiments for drug library screening, drug–target identification, binding characterization, and interaction studies
Our scientists provide end-to-end support — from experimental design and sample preparation to spectral analysis and data interpretation.​​
For sample submission and inquiries, please contact ✉ drugdiscovery@cvvt.hk
LC–MS Service
In addition to NMR, our Liquid Chromatography–Mass Spectrometry (LC–MS) platform expands molecular profiling capabilities.
Equipped with Ion Mobility Spectrometry (IMS), it enables the high-resolution and high-sensitivity analysis of small molecules, metabolites, lipids, and complex samples — particularly useful for distinguishing isomers, conformers, and isobaric compounds.
Our LC–MS services support the following applications:
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Untargeted lipidomics/metabolomics: Investigating alterations in the host metabolome and lipidome under healthy and diseased conditions
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Enzymatic reaction characterization: Quantifying substrates and products in specific enzymatic reactions involving lipids or metabolites
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Drug/compound quantification and metabolite identification: Performing pharmacokinetic studies and identifying specific metabolites of target compounds in tissues, plasma, and cells
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Complex mixture characterization: Profiling multiple components in herbal extracts or natural products
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Custom assays: Conducting tailored investigations for small molecules, including protein–ligand binding studies and related analyses
For sample submission and inquiries, please contact ✉ drugdiscovery@cvvt.hk
Drug Target Identification and Interaction Site Mapping
We offer two complementary strategies to elucidate drug–target interactions and identify unknown targets.
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WaterLOGSY NMR Method
A well-established ligand-observed NMR approach for validating interactions between small molecules and their putative protein targets.
Our streamlined workflow has been successfully applied to multiple potent antimicrobial compounds identified through chemical library screening. -
Formaldehyde Crosslinking–Assisted Pulldown Method
This method involves non-specific crosslinking of drugs to beads using formaldehyde, followed by pulldown assays with cell lysate or protein mixture.
Our optimized protocol minimizes chemical modification while retaining the ability to map binding sites on target proteins through detailed mass spectrometric (MS) analysis.
For sample submission and inquiries, please contact ✉ drugdiscovery@cvvt.hk
Drug Library Virtual Screening
Our in silico virtual screening platform enables fast, high-throughput, structure-based docking covering extensive chemical libraries ranging from 300,000 to 10 billion compounds.
Through clustering analysis of docking results, we can identify key binding residues within target protein and the top-ranking compounds.
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This platform can be seamlessly integrated with our biological validation services — including WaterLOGSY, STD-NMR, and formaldehyde pulldown assays — for confirming and characterizing hit compounds.
