Drug Discovery Platform
Unlocking Molecular Interactions for Complex Biology
Our Drug Discovery Platform integrates state-of-the-art analytical technologies with expert scientific support to advance molecular research and therapeutic development.We provide comprehensive analytical and discovery services focused on drug–target interactions, drug library virtual screening, and molecular characterization, as well as studies of small molecules, metabolomics, and lipidomics in tissue, plasma, and cell samples.By combining Nuclear Magnetic Resonance (NMR), Liquid Chromatography–Mass Spectrometry (LC–MS), and in silico computational approaches, our multidisciplinary team delivers reliable, publication-ready insights that accelerate lead identification and translational discovery.
NMR Service
Our Nuclear Magnetic Resonance (NMR) platform offers comprehensive small-molecule and biomolecular analyses, with workflows optimized for throughput and data quality.
With decades of experience and a suite of robustly validated applications, our NMR services include:
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Performing qualitative and quantitative analysis of small molecules
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Determining the structures of organic molecules and small peptides
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Assessing the purity of small-molecule samples or mixtures
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Conducting metabolomic studies on biological samples (urine, serum, tissue, and cell culture)
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Applying ligand-observed NMR (WaterLOGSY and STD-NMR) experiments for drug library screening, drug–target identification, binding characterization, and interaction studies
Our scientists provide end-to-end support — from experimental design and sample preparation to spectral analysis and data interpretation.
For sample submission and inquiries, please contact ✉ drugdiscovery@cvvt.hk
Drug Target Identification and Interaction Site Mapping
We offer two complementary strategies to elucidate drug–target interactions and identify unknown targets.
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WaterLOGSY NMR Method
A well-established ligand-observed NMR approach for validating interactions between small molecules and their putative protein targets.
Our streamlined workflow has been successfully applied to multiple potent antimicrobial compounds identified through chemical library screening. -
Formaldehyde Crosslinking–Assisted Pulldown Method
This method involves non-specific crosslinking of drugs to beads using formaldehyde, followed by pulldown assays with cell lysate or protein mixture.
Our optimized protocol minimizes chemical modification while retaining the ability to map binding sites on target proteins through detailed mass spectrometric (MS) analysis.
For sample submission and inquiries, please contact ✉ drugdiscovery@cvvt.hk
Drug Library Virtual Screening
Our in silico virtual screening platform enables fast, high-throughput, structure-based docking covering extensive chemical libraries ranging from 300,000 to 10 billion compounds.
Through clustering analysis of docking results, we can identify key binding residues within target protein and the top-ranking compounds.
This platform can be seamlessly integrated with our biological validation services — including WaterLOGSY, STD-NMR, and formaldehyde pulldown assays — for confirming and characterizing hit compounds.
