HKU’s innovative research novelties excel at 48th International Exhibition of Inventions of Geneva
29 Apr 2023
The University of Hong Kong (HKU) triumphed at the 48th International Exhibition of Inventions of Geneva, winning a total of 19 awards, including two special grand prizes Invention & Innovation CAI Award (China Delegation), and Prize of the Delegation of Malaysia. The results were announced yesterday (April 28).
Research teams from Faculty of Architecture, Faculty of Engineering, Faculty of Science, LKS Faculty of Medicine, and two HKU Inno Laboratories, established under the Hong Kong Government's InnoHK programme, garnered two special grand prizes, one Gold Medal with the Congratulations of the Jury, six Gold Medals, six Silver Medals and four Bronze Medals with their innovations in the event. [...]
HKUMed established the first human respiratory organoid culture system and unveils a novel mechanism for the high transmissibility of SARS-CoV-2 Omicron variant
18 Apr 2023
A research team led by Dr Zhou Jie and Professor Yuen Kwok-yung from State Key Laboratory for Emerging Infectious Diseases and the Department of Microbiology, School of Clinical Medicine, LKS Faculty of Medicine, the University of Hong Kong (HKUMed), together with Professor Hans Clevers from Hubrecht Institute, the Netherlands, a pioneer of organoid technology, and Professor Jiang Shibo from Fudan University investigated the infection and replication capacity of the Omicron BA.5 and other variants in human respiratory organoids established by the team. The findings were published in the latest issue of Proceedings of the National Academy of Sciences of the United States of America (PNAS) [...]
HKUMed Identifies Novel Host Protease Determinants for SARS-CoV-2 Infection
21 Feb 2023
Researchers from Department of Microbiology, School of Clinical Medicine, LKS Faculty of Medicine, the University of Hong Kong (HKUMed), has identified novel host protease determinants, that facilitate the infection of SARS-CoV-2, including the Omicron variant, which provided new targets for combating the pandemic. In addition to the host protease determinants, members from the membrane-type matrix metalloproteinase (MT-MMP) and a disintegrin and metalloproteinase (ADAM) families were found to be able to mediate SARS-CoV-2 entry, with an increase efficiency against Omicron BA.1. This finding suggests that a new treatment strategy at MMP inhibition should be explored to effectively combat Omicron BA.1 and other Omicron sublineages. The research has now been published in the international scientific journal Science Advances [...]
Intranasal Covid19 vaccine developed by HKU team approved for emergency use in the Mainland
05 Dec 2022
An intranasal Covid19 vaccine developed by researchers at the University of Hong Kong (HKU) in collaboration with Xiamen University and Wantai pharmaceutical has gained approval from the Chinese authorities for emergency use in the Mainland.
Wantai BioPharm announced today (Dec 5) that the nasal vaccine has obtained the critical green light from the Chinese National Medical Products Administration. The company is targeting to manufacture 200 million doses (one dose per person) in the next six months. [...]
Thirty-eight HKU academics listed among the most highly cited researchers in 2022
15 Nov 2022
The University of Hong Kong ranks 26th globally among all institutions this year with thirty-eight academics named on the list of “Highly Cited Researchers 2022” from Clarivate.
A total of 6,938 researchers from 69 countries and regions are named Highly Cited Researchers in 2022. Overall, there are 3,981 awards in specific fields and 3,244 awards for cross-field impact, totalling 7,225 awards, after taking into account that some researchers are recognised in multiple research fields this year. [...]
HKUMed, University of Michigan and Johannes Kepler University Linz jointly discover the pan-coronavirus antiviral activity and mechanism of the molecularly engineered banana lectin H84T-BanLec
24 Oct 2022
Researchers from Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine of The University of Hong Kong (HKUMed), University of Michigan, Johannes Kepler University Linz, and other overseas institutions revealed insights into the broad-spectrum ‘pan-coronavirus’ antiviral activity and mechanism of the molecularly engineered banana lectin ‘H84T-BanLec’. The findings have been recently published in the scientific journal Cell Reports Medicine [...]
HKUMed & HKUST joint study reports broadly neutralising antibody that protects Syrian hamsters against SARS-CoV-2 Omicron variants
11 Jul 2022
Researchers at the AIDS Institute, The University of Hong Kong (HKU), Department of Microbiology, School of Clinical Medicine, the LKS Faculty of Medicine of The University of Hong Kong (HKUMed) and the State Key Laboratory of Emerging Infectious Diseases, HKU, together with structural biologists at The Hong Kong University of Science and Technology (HKUST), have demonstrated that ZCB11, a broadly neutralising antibody derived from a local mRNA-vaccinee against the spreading Omicron variants of SARS-CoV-2, displays potent antiviral activities against all variants of concern (VOCs), including the dominantly spreading Omicron BA.1, BA1.1 and BA.2. Critically, either prophylactic or therapeutic ZCB11 administration protects lung infection against Omicron viral challenge in golden Syrian hamsters. The research paper is now published online in Nature Communications [...]
HKUMed discovers a novel vaccine strategy to prevent SARS-CoV-2 nasal infection
29 Dec 2021
Researchers at the Department of Microbiology and State Key Laboratory of Emerging Infectious Diseases, LKS Faculty of Medicine of The University of Hong Kong (HKUMed) have conducted a comprehensive study for identifying an effective vaccine regimen in preventing SARS-CoV-2 nasal infection. The study demonstrated that a combination of intramuscular PD1-based receptor-binding domain (RBD) DNA vaccine (PD1-RBD-DNA) prime and intranasal live attenuated influenza-based vaccine (LAIV-HK68-RBD) boost vaccination regimen induced the strongest mucosal broadly neutralising antibodies and lung resident memory CD8 T cells, which prevented live SARS-CoV-2 nasal challenges in two animal models. The full research article is now online in the journal of EBioMedicine published by The Lancet [...]
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